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1-Dichloro-acetyl-3,3-dimethyl-2,6-diphenyl-piperidin-4-one.

ABSTRACT: In the title compound, C(21)H(21)Cl(2)NO(2), the piperidine ring adopts a distorted boat conformation. The two phenyl rings are approximately perpendicular to each other, with a dihedral angle of 86.12 (7)°. Mol-ecules are linked into centrosymmetric dimers by pairs of bifurcated C-H⋯O hydrogen bonds, forming R(2) (2)(10) and R(2) (2)(14) ring motifs, and an intramolecular C-H⋯O link also occurs.

SUBMITTER: Kavitha T

PROVIDER: S-EPMC2967931 | biostudies-literature |

REPOSITORIES: biostudies-literature

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1-Dichloro-acetyl-t-3,t-5-dimethyl-r-2,c-6-diphenyl-piperidin-4-one.

Project description:In the title compound, C21H21Cl2NO2, the piperidine ring adopts a distorted boat conformation. The phenyl rings substituted at the 2- and 6-positions of the piperidine ring subtend angles of 87.9 (7) and 70.8 (9)°, respectively, with the best plane through the piperidine ring. In the crystal, mol-ecules are connected by C-H⋯O and C-H⋯Cl inter-actions into layers in the ab plane.

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1-Chloro-acetyl-3,3-dimethyl-2,6-di-phenyl-piperidin-4-one.

Project description:In the mol-ecule of the title compound, C(21)H(22)ClNO(2), the piperidine ring adopts a distorted boat conformation. The two phenyl rings are nearly orthogonal to each other with a dihedral angle of 87.1?(1)°. In the crystal structure, the mol-ecules are linked into a three-dimensional network by C-H?O and C-H?? inter-actions.

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3,3-Dimethyl-cis-2,6-di-p-tolyl-piperidin-4-one.

Project description:In the title mol-ecule, C(21)H(25)NO, the piperidine ring adopts a chair conformation. The benzene rings and one of the methyl groups attached to the piperidine ring have equatorial orientations. The dihedral angle between the two benzene rings is 72.53?(9)°. In the crystal, mol-ecules are linked by N-H?O hydrogen bonds. Weak C-H?? inter-actions involving the benzene rings are also present in the crystal structure.

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1,3-Dimethyl-2,6-diphenyl-piperidin-4-one.

Project description:In the title moleclue, C(19)H(21)NO, the 4-piperidone ring adopts a chair conformation in which the two benzene rings and the methyl group attached to C atoms all have equatorial orientations. In the crystal structure, centrosymmetric dimers are formed through weak inter-molecular C-H?O hydrogen bonds [the dihedral angle between the aromatic rings is 58.51?(5)°].

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(E)-N'-(3,3-Dimethyl-2,6-diphenyl-piperidin-4-yl-idene)isonicotinohydrazide.

Project description:In the title mol-ecule, C(25)H(26)N(4)O, the piperidine ring adopts a chair conformation, with the plane through the four coplanar atoms making dihedral angles of 84.76?(6), 82.28?(5) and 81.91?(6)° with the pyridine-ring and the phenyl rings at the 2 and 6 positions, respectively. The pyridine ring makes dihedral angles of 64.13?(8) and 10.75?(8)° with the phenyl rings at the 2 and 6 positions, respectively. The dihedral angle between the two phenyl rings is 53.57?(8)°. The phenyl rings and one of the methyl groups at position 3 have an equatorial orientation. In the crystal, mol-ecules are linked by N-H?O and C-H?O hydrogen bonds.

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1-Chloro-acetyl-2,6-bis-(2-chloro-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(21)H(20)Cl(3)NO(2), the piperidin-4-one ring adopts a boat conformation. The two 2-chloro-phenyl groups are approximately perpendicular to each other, making a dihedral angle of 74.07 (8)°.

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Project description:The piperidone ring in the title compound, C(23)H(26)ClNO(4), adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597 (2) and 0.630 (2) Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1 (1)°, and a C-H⋯π intra-molecular inter-action is observed. The crystal packing is stabilized by a C-H⋯O inter-molecular inter-action, generating a chain with a C(9) motif along the a axis.

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1-Bromo-acetyl-2,6-bis-(4-methoxy-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(26)BrNO(4), the piperidinone ring adopts a boat conformation. The dihedral angle between the two benzene rings is 70.9 (1)°. The two meth-oxy groups are close to coplanar with the attached benzene rings [C-C-O-C torsion angles of 6.3 (5) and 16.4 (4)°]. A weak C-H⋯Br intra-molecular inter-action is observed. In the crystal structure, mol-ecules are linked into a chain along [101] by inter-molecular C-H⋯O hydrogen bonds. A short inter-molecular Br⋯O contact [3.063 (2) Å] is observed.

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1-Acetyl-c-3,t-3-dimethyl-r-2,c-6-diphenyl-piperidin-4-one.

Project description:In the title compound, C(21)H(23)NO(2), the piperidine ring adopts a distorted boat conformation. The two phenyl rings form dihedral angles of 64.6?(1) and 87.8?(1)° with the best plane through the piperidine ring. The crystal packing is governed by inter-molecular C-H?O inter-actions.

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1-Chloro-acetyl-2,6-bis-(2-chloro-phen-yl)-3,5-dimethyl-piperidin-4-one oxime.

Project description:In the title compound, C(21)H(21)Cl(3)N(2)O(2), the piperidine ring adopts a distorted boat conformation. One of the chloro-phenyl rings is almost perpendicular to the best plane through piperidine ring, making a dihedral angle of 88.7?(1)°, whereas the other ring is twisted by 71.8?(1)°. The crystal packing is stabilized by inter-molecular C-H?O, C-H?Cl and O-H?O inter-actions.

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