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(8S,9R,10S,11S,13S,14S,16S,17R)-4,4-Dichloro-16?-methyl-3,20-dioxo-17,21-bis-(propano-yloxy)-5?,8?-epoxy-pregna-1,9-diene.

ABSTRACT: The title compound, C(28)H(34)Cl(2)O(7), is a derivative of the glucocorticoid steroid beclomethasone dipropionate. It features an expoxide linkage [angle at oxygen = 96.6?(2)°]. The dichlorocyclohexenone ring adopts an envelope conformation, with the C atom bearing the two Cl substituents representing the flap. The dichloro-methyl C atom deviates by 0.471?(4)?Å from the plane defined by the other five atoms, whose maximum r.m.s. deviation is 0.04?Å.

SUBMITTER: Ketuly KA

PROVIDER: S-EPMC2970074 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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(8S,9R,10S,11S,13S,14S,16S,17R)-4,4-Dichloro-16β-methyl-3,20-dioxo-17,21-bis-(propano-yloxy)-5β,8β-epoxy-pregna-1,9-diene.

Ketuly Kamal Aziz KA A Hadi A Hamid AH Ng Seik Weng SW

Acta crystallographica. Section E, Structure reports online 20090722 Pt 9

The title compound, C(28)H(34)Cl(2)O(7), is a derivative of the glucocorticoid steroid beclomethasone dipropionate. It features an expoxide linkage [angle at oxygen = 96.6 (2)°]. The dichlorocyclohexenone ring adopts an envelope conformation, with the C atom bearing the two Cl substituents representing the flap. The dichloro-methyl C atom deviates by 0.471 (4) Å from the plane defined by the other five atoms, whose maximum r.m.s. deviation is 0.04 Å. ...[more]

PMID: 21577621

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