Ontology highlight
ABSTRACT:
SUBMITTER: Blom HJ
PROVIDER: S-EPMC2970514 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Blom Henk J HJ Shaw Gary M GM den Heijer Martin M Finnell Richard H RH
Nature reviews. Neuroscience 20060901 9
Neural tube closure takes place during early embryogenesis and requires interactions between genetic and environmental factors. Failure of neural tube closure is a common congenital malformation that results in morbidity and mortality. A major clinical achievement has been the use of periconceptional folic acid supplements, which prevents approximately 50-75% of cases of neural tube defects. However, the mechanism underlying the beneficial effects of folic acid is far from clear. Biochemical, ge ...[more]