Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC2970762 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Li Zhiping Z Jiao Xuanmao X Wang Chenguang C Shirley L Andrew LA Elsaleh Hany H Dahl Olav O Wang Min M Soutoglou Evi E Knudsen Erik S ES Pestell Richard G RG
Cancer research 20101012 21
The DNA damage response (DDR) activates downstream pathways including cell cycle checkpoints. The cyclin D1 gene is overexpressed or amplified in many human cancers and is required for gastrointestinal, breast, and skin tumors in murine models. A common polymorphism in the human cyclin D1 gene is alternatively spliced, resulting in cyclin D1a and D1b proteins that differ in their carboxyl terminus. Cyclin D1 overexpression enhances DNA damage-induced apoptosis. The role of cyclin D1 and the alte ...[more]