Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC4102655 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Cancer research 20140515 14
The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates the retinoblastoma protein (pRb) and nuclear respiratory factor (NRF1) proteins. The abundance of cyclin D1 determines estrogen-dependent gene expression in the mammary gland of mice. Using estradiol (E2) and an E2-dendrimer conjugate that is excluded from the nucleus, we demonstrate that E2 delays the DNA damage response (DDR) via an extranuclear mechanism. The E2-induced DDR required extranuclear cyclin D1, w ...[more]