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Trimethyl 5-(2-chloro-4-fluoro-phen-yl)-2-phenyl-pyrrolidine-2,3,4-tricarboxyl-ate.

ABSTRACT: The title compound, C(22)H(21)ClFNO(6), was synthesized by the 1,3-dipolar cyclo-addition reaction of dimethyl maleate, methyl 2-amino-2-phenyl-acetate and 2-chloro-4-fluoro-benzaldehyde. The pyrrolidine ring possesses an envelope conformation and the two benzene rings are oriented at a dihedral angle of 68.28?(7)°. Weak inter-molecular C-H?O hydrogen bonding is present in the crystal structure. One methyl group is disordered over two positions with a site-occupancy ratio of 0.651?(12):0.349?(12).

SUBMITTER: He L 

PROVIDER: S-EPMC2971169 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Trimethyl 5-(2-chloro-4-fluoro-phen-yl)-2-phenyl-pyrrolidine-2,3,4-tricarboxyl-ate.

He Long L   Chen Lian-Mei LM  

Acta crystallographica. Section E, Structure reports online 20091031 Pt 11

The title compound, C(22)H(21)ClFNO(6), was synthesized by the 1,3-dipolar cyclo-addition reaction of dimethyl maleate, methyl 2-amino-2-phenyl-acetate and 2-chloro-4-fluoro-benzaldehyde. The pyrrolidine ring possesses an envelope conformation and the two benzene rings are oriented at a dihedral angle of 68.28 (7)°. Weak inter-molecular C-H⋯O hydrogen bonding is present in the crystal structure. One methyl group is disordered over two positions with a site-occupancy ratio of 0.651 (12):0.349 (12  ...[more]

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