Ontology highlight
ABSTRACT:
SUBMITTER: Vadola PA
PROVIDER: S-EPMC2971677 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20091101 45
We report a catalytic intramolecular coupling between terminal unactivated alkynes and sp(3) C-H bonds via through-space hydride transfer (HT-cyclization of alkynes). This method enables one-step preparation of complex heterocyclic compounds by alpha-alkenylation of readily available cyclic ethers and amines. We show that PtI(4) is an effective Lewis acid catalyst for the activation of terminal alkynes for hydride attack and subsequent C-C bond formation. In addition, we have shown that the acti ...[more]