Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC6972843 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200121 1
Transition metal catalyzed Sonogashira cross-coupling of terminal alkynes with aryl(vinyl) (pseudo)halides has been successfully extended to alkyl halides for the synthesis of functionalized internal alkynes. The direct alkynylation of remote unfunctionalized sp<sup>3</sup> carbon by terminal alkynes remains difficult to realize. We report herein an approach to this synthetic challenge by developing two catalytic remote sp<sup>3</sup> carbon alkynylation protocols. In the presence of a catalytic ...[more]