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N-Cyclo-hexyl-N-propyl-benzene-sulfonamide.

ABSTRACT: The title compound, C(15)H(23)NO(2)S, synthesized by N-methyl-ation of cyclo-hexyl-amine sulfonamide with propyl iodide, is of inter-est as a precursor to biologically active sulfur-containing heterocyclic compounds. The cyclo-hexyl ring exists in the chair form and the dihedral angle between the ring plane of the benzene ring and that of the cyclo-hexyl ring is 50.13 (9)°.

SUBMITTER: Haider Z

PROVIDER: S-EPMC2971915 | biostudies-literature |

REPOSITORIES: biostudies-literature

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N-Cyclo-hexyl-4-meth-yl-N-propyl-benzene-sulfonamide.

Project description:The title compound, C(16)H(25)NO(2)S, is a sulfonamide derivative with the substitution of propyl and cyclo-hexyl groups at the N atom. The least-squares plane through all six C atoms of the cyclo-hexyl ring forms a dihedral angle of 58.88?(12)° with the toluene ring. No hydrogen-bonding inter-actions are present in the crystal structure.

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Project description:The structure of the title sulfonamide, C(12)H(15)Cl(2)NO(2)S, features a distorted tetra-hedral geometry for the S atom [maximum deviation: O-S-O = 120.23?(14)°]. One of the sulfonamide O atoms is coplanar with the benzene ring [C-C-S-O torsion angle = -174.5?(2)°], whereas the other lies well above the plane [C-C-S-O = 57.0?(3)°]. A chair conformation is found for the cyclo-hexyl ring. In the crystal, supra-molecular chains aligned along the c axis are formed via N-H?O hydrogen bonds; these are consolidated in the three-dimensional packing by C-H?O contacts involving the second sulfonamide O atom.

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4-Bromo-N-cyclo-hexyl-benzene-sulfonamide.

Project description:The title compound, C(12)H(16)BrNO(2)S, adopts an L-shaped conformation with the central C-S-N-C torsion angle being -77.8?(3)°. The crystal packing features N-H?O hydrogen bonds, which lead to C(4) chains propagating in [010]; the second O atom is involved in short intra-molecular C-H?O contacts.

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Project description:The asymmetric unit of the title compound, C(13)H(18)N(2)O(3)S, contains two mol-ecules with similar conformations. In both mol-ecules, the cyclo-hexyl rings adopt chair conformations, with the attached N atom in an equatorial orientation and an intra-molecular N-H?O hydrogen bond generates an S(7) ring. In the crystal, N-H?O hydrogen bonds link the mol-ecules and a C-H?O hydrogen bond is also observed. The crystal studied was a racemic twin.

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Project description:In the title mol-ecule, C(13)H(19)NO(3)S, the S atom has a distorted tetra-hedral geometry with an O-S-O bond angle of 120.39 (18)°. The cyclo-hexane ring has a chair conformation. In the crystal, mol-ecules are connected by inter-molecular N-H⋯O hydrogen bonds, forming zigzag hydrogen-bonded chains directed along the c axis.

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N-Cyclo-hexyl-N-ethyl-4-methyl-benzene-sulfonamide.

Project description:The title compound, C(15)H(23)NO(2)S, contains cyclo-hexyl and ethyl substituents on the sulfonamide N atom and the cyclo-hexyl ring adopts a classic chair conformation. The dihedral angle between the benzene ring plane and the mean plane through the six atoms of the cyclo-hexyl ring is 59.92?(6)°. In the crystal structure, C-H?O hydrogen bonds link mol-ecules into sheets extending in the bc plane.

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N-Benzyl-N-cyclo-hexyl-4-methyl-benzene-sulfonamide.

Project description:In the title compound, C(20)H(25)NO(2)S, the cyclo-hexyl ring exists in a chair form and the mean plane through all six atoms makes dihedral angles of 56.12?(9) and 55.19?(10)° with the benzene and phenyl rings, respectively. The dihedral angle between the two aromatic rings is 77.23?(7)°. A weak intra-molecular C-H?O interaction occurs.

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4-Chloro-N-cyclo-hexyl-benzene-sulfonamide.

Project description:The title compound, C(12)H(16)ClNO(2)S, adopts an L-shaped conformation, with the central C-S-N-C torsion angle being -78.0?(2)°. The cyclo-hexyl ring adopts a chair conformation. In the crystal, adjacent mol-ecules are connected by pairs of N-H?O hydrogen bonds around an inversion centre, forming cyclic dimers [graph set R(2) (2)(8)].

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N-Cyclo-hexyl-N-ethyl-benzene-sulfonamide.

Project description:The title compound, C(14)H(21)NO(2)S, synthesized by N-methyl-ation of cyclo-hexyl-amine sulfonamide with ethyl iodide is of inter-est as a precursor to biologically active sulfur-containing heterocyclic compounds. There are two independent mol-ecules in the asymmetric unit. The dihedral angles between the mean planes of the phenyl ring and the cyclo-hexyl ring are 40.29?(11) and 37.91?(13)° in the two mol-ecules.

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N-Benzyl-N-cyclo-hexyl-benzene-sulfonamide.

Project description:In the title compound, C(19)H(23)NO(2)S, the cyclo-hexyl ring exists in a chair form. The dihedral angle between the two terminal phenyl rings is 86.70?(6)°. No significant inter-actions are observed except for a weak intra-molecular C-H?O hydrogen bond.

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