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4-Chloro-7-hydr-oxy-6-methyl-1,7-naphthyridin-8(7H)-one.

ABSTRACT: The title compound, C(9)H(7)ClN(2)O(2), was prepared by reaction of methyl 4-chloro-3-(prop-1-yn-yl)picolinate with hydroxy-l-amine in MeOH/KOH solution. The two essentially planar mol-ecules which make up the asymmetric unit have almost identical geometries and and are linked into dimeric aggregates via pairs of O-H?O hydrogen bonds. These aggregates have almost perfect inversion symmetry; however, quite unusually, the inversion center of the dimer does not coincide with the crystallographic inversion center.

SUBMITTER: Bunker KD

PROVIDER: S-EPMC2972179 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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4-Chloro-7-hydr-oxy-6-methyl-1,7-naphthyridin-8(7H)-one.

Bunker Kevin D KD Nukui Seiji S Rheingold Arnold L AL Dipasquale Antonio A Yanovsky Alex A

Acta crystallographica. Section E, Structure reports online 20091128 Pt 12

The title compound, C(9)H(7)ClN(2)O(2), was prepared by reaction of methyl 4-chloro-3-(prop-1-yn-yl)picolinate with hydroxy-l-amine in MeOH/KOH solution. The two essentially planar mol-ecules which make up the asymmetric unit have almost identical geometries and and are linked into dimeric aggregates via pairs of O-H⋯O hydrogen bonds. These aggregates have almost perfect inversion symmetry; however, quite unusually, the inversion center of the dimer does not coincide with the crystallographic in ...[more]

PMID: 21578955

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