Comparative survival analysis of breast cancer microarray studies identifies important prognostic genetic pathways.

ABSTRACT:

Background

An estimated 12% of females in the United States will develop breast cancer in their lifetime. Although, there are advances in treatment options including surgery and chemotherapy, breast cancer is still the second most lethal cancer in women. Thus, there is a clear need for better methods to predict prognosis for each breast cancer patient. With the advent of large genetic databases and the reduction in cost for the experiments, researchers are faced with choosing from a large pool of potential prognostic markers from numerous breast cancer gene expression profile studies.

Methods

Five microarray datasets related to breast cancer were examined using gene set analysis and the cancers were categorized into different subtypes using a scoring system based on genetic

SUBMITTER: Miecznikowski JC 

PROVIDER: S-EPMC2972286 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature