Leukaemogenesis: more than mutant genes.
Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC2972637 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Leukaemogenesis: more than mutant genes.
Chen Jianjun J Odenike Olatoyosi O Rowley Janet D JD
Nature reviews. Cancer 20100101 1
Acute leukaemias are characterized by recurring chromosomal aberrations and gene mutations that are crucial to disease pathogenesis. It is now evident that epigenetic modifications, including DNA methylation and histone modifications, substantially contribute to the phenotype of leukaemia cells. An additional layer of epigenetic complexity is the pathogenetic role of microRNAs in leukaemias, and their key role in the transcriptional regulation of tumour suppressor genes and oncogenes. The geneti ...[more]
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