Ontology highlight
ABSTRACT:
SUBMITTER: Stacey SN
PROVIDER: S-EPMC2973331 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Stacey Simon N SN Sulem Patrick P Masson Gisli G Gudjonsson Sigurjon A SA Thorleifsson Gudmar G Jakobsdottir Margret M Sigurdsson Asgeir A Gudbjartsson Daniel F DF Sigurgeirsson Bardur B Benediktsdottir Kristrun R KR Thorisdottir Kristin K Ragnarsson Rafn R Scherer Dominique D Hemminki Kari K Rudnai Peter P Gurzau Eugene E Koppova Kvetoslava K Botella-Estrada Rafael R Soriano Virtudes V Juberias Pablo P Saez Berta B Gilaberte Yolanda Y Fuentelsaz Victoria V Corredera Cristina C Grasa Matilde M Höiom Veronica V Lindblom Annika A Bonenkamp Johannes J JJ van Rossum Michelle M MM Aben Katja K H KK de Vries Esther E Santinami Mario M Di Mauro Maria G MG Maurichi Andrea A Wendt Judith J Hochleitner Pia P Pehamberger Hubert H Gudmundsson Julius J Magnusdottir Droplaug N DN Gretarsdottir Solveig S Holm Hilma H Steinthorsdottir Valgerdur V Frigge Michael L ML Blondal Thorarinn T Saemundsdottir Jona J Bjarnason Hjördis H Kristjansson Kristleifur K Bjornsdottir Gyda G Okamoto Ichiro I Rivoltini Licia L Rodolfo Monica M Kiemeney Lambertus A LA Hansson Johan J Nagore Eduardo E Mayordomo José I JI Kumar Rajiv R Karagas Margaret R MR Nelson Heather H HH Gulcher Jeffrey R JR Rafnar Thorunn T Thorsteinsdottir Unnur U Olafsson Jon H JH Kong Augustine A Stefansson Kari K
Nature genetics 20090705 8
In a follow-up to our previously reported genome-wide association study of cutaneous basal cell carcinoma (BCC), we describe here several new susceptibility variants. SNP rs11170164, encoding a G138E substitution in the keratin 5 (KRT5) gene, affects risk of BCC (OR = 1.35, P = 2.1 x 10(-9)). A variant at 9p21 near CDKN2A and CDKN2B also confers susceptibility to BCC (rs2151280[C]; OR = 1.19, P = 6.9 x 10(-9)), as does rs157935[T] at 7q32 near the imprinted gene KLF14 (OR = 1.23, P = 5.7 x 10(-1 ...[more]