Common sequence variants on 20q11.22 confer melanoma susceptibility.
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ABSTRACT:
SUBMITTER: Brown KM
PROVIDER: S-EPMC2755512 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Common sequence variants on 20q11.22 confer melanoma susceptibility.
Brown Kevin M KM Macgregor Stuart S Montgomery Grant W GW Craig David W DW Zhao Zhen Zhen ZZ Iyadurai Kelly K Henders Anjali K AK Homer Nils N Campbell Megan J MJ Stark Mitchell M Thomas Shane S Schmid Helen H Holland Elizabeth A EA Gillanders Elizabeth M EM Duffy David L DL Maskiell Judith A JA Jetann Jodie J Ferguson Megan M Stephan Dietrich A DA Cust Anne E AE Whiteman David D Green Adele A Olsson Håkan H Puig Susana S Ghiorzo Paola P Hansson Johan J Demenais Florence F Goldstein Alisa M AM Gruis Nelleke A NA Elder David E DE Bishop Julia Newton JN Kefford Richard F RF Giles Graham G GG Armstrong Bruce K BK Aitken Joanne F JF Hopper John L JL Martin Nicholas G NG Trent Jeffrey M JM Mann Graham J GJ Hayward Nicholas K NK
Nature genetics 20080518 7
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases. ...[more]
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