Ontology highlight
ABSTRACT:
SUBMITTER: Shvartsburg AA
PROVIDER: S-EPMC2973842 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Shvartsburg Alexandre A AA Creese Andrew J AJ Smith Richard D RD Cooper Helen J HJ
Analytical chemistry 20101001 19
Many proteins and proteolytic peptides incorporate the same post-translational modification (PTM) at different sites, creating multiple localization variants with different functions or activities that may coexist in cells. Current analytical methods based on liquid chromatography (LC) followed by tandem mass spectrometry (MS/MS) are challenged by such isomers that often coelute in LC and/or produce nonunique fragment ions. The application of ion mobility spectrometry (IMS) was explored, but suc ...[more]