Ontology highlight
ABSTRACT:
SUBMITTER: Alba R
PROVIDER: S-EPMC2974579 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Alba Raul R Bradshaw Angela C AC Coughlan Lynda L Denby Laura L McDonald Robert A RA Waddington Simon N SN Buckley Suzanne M K SM Greig Jenny A JA Parker Alan L AL Miller Ashley M AM Wang Hongjie H Lieber Andre A van Rooijen Nico N McVey John H JH Nicklin Stuart A SA Baker Andrew H AH
Blood 20100707 15
A major limitation for adenoviral transduction in vivo is the profound liver tropism of adenovirus type 5 (Ad5). Recently, we demonstrated that coagulation factor X (FX) binds to Ad5-hexon protein at high affinity to mediate hepatocyte transduction after intravascular delivery. We developed novel genetically FX-binding ablated Ad5 vectors with lower liver transduction. Here, we demonstrate that FX-binding ablated Ad5 predominantly localize to the liver and spleen 1 hour after injection; however, ...[more]