Ontology highlight
ABSTRACT:
SUBMITTER: Wilbur JD
PROVIDER: S-EPMC2975025 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Wilbur Jeremy D JD Hwang Peter K PK Ybe Joel A JA Lane Michael M Sellers Benjamin D BD Jacobson Matthew P MP Fletterick Robert J RJ Brodsky Frances M FM
Developmental cell 20100501 5
Clathrin-coated vesicle formation is responsible for membrane traffic to and from the endocytic pathway during receptor-mediated endocytosis and organelle biogenesis, influencing how cells relate to their environment. Generating these vesicles involves self-assembly of clathrin molecules into a latticed coat on membranes that recruits receptors and organizes protein machinery necessary for budding. Here we define a molecular mechanism regulating clathrin lattice formation by obtaining structural ...[more]