Ontology highlight
ABSTRACT:
SUBMITTER: Biancospino M
PROVIDER: S-EPMC6823378 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Biancospino Matteo M Buel Gwen R GR Niño Carlos A CA Maspero Elena E Scotto di Perrotolo Rossella R Raimondi Andrea A Redlingshöfer Lisa L Weber Janine J Brodsky Frances M FM Walters Kylie J KJ Polo Simona S
Nature communications 20191031 1
Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Unique functions for these evolutionary conserved paralogs remain elusive, and their role in clathrin-mediated endocytosis in mammalian cells is debated. Here, we find and structurally characterize a direct and selective interaction between CLCa and the long isoform of the actin motor protein myosin VI, which is expressed exclusively in highly polarized tissues. Using genetically-reconstituted Caco-2 cysts ...[more]