Unknown

Dataset Information

0

IKK? modulates RSV-induced NF-?B-dependent gene transcription.


ABSTRACT: Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-?B (NF-?B). In this study we have investigated the role of the non canonical I?B kinase (IKK)? in modulating RSV-induced NF-?B activation. Our results show that inhibition of IKK? activation results in significant impairment of viral-induced NF-?B-dependent gene expression, through a reduction in NF-?B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absence of IKK? results in a significant decrease of RSV-induced NF-?B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-?B-dependent gene expression, known to regulate NF-?B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK? regulates viral-induced cellular signaling.

SUBMITTER: Bao X 

PROVIDER: S-EPMC2975836 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

IKKε modulates RSV-induced NF-κB-dependent gene transcription.

Bao Xiaoyong X   Indukuri Hemalatha H   Liu Tianshuang T   Liao Sui-Ling SL   Tian Bing B   Brasier Allan R AR   Garofalo Roberto P RP   Casola Antonella A  

Virology 20101018 2


Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-κB (NF-κB). In this study we have investigated the role of the non canonical IκB kinase (IKK)ε in modulating RSV-induced NF-κB activation. Our results show that inhibiti  ...[more]

Similar Datasets

| S-EPMC3369814 | biostudies-literature
| S-EPMC2906898 | biostudies-literature
| S-EPMC4172221 | biostudies-literature
| S-EPMC4510711 | biostudies-literature
| S-EPMC3945882 | biostudies-literature
| S-EPMC3150212 | biostudies-literature
2015-07-20 | GSE69153 | GEO
| S-EPMC6267954 | biostudies-literature
| S-EPMC3983614 | biostudies-literature
| S-EPMC3268328 | biostudies-literature