Endurance exercise training in myostatin null mice.
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ABSTRACT:
SUBMITTER: Savage KJ
PROVIDER: S-EPMC2976492 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Endurance exercise training in myostatin null mice.
Savage Kathleen J KJ McPherron Alexandra C AC
Muscle & nerve 20100901 3
The growth factor myostatin (Mstn) is a negative regulator of skeletal muscle mass. Mstn(-/-) muscles are hypertrophied, stronger, and more glycolytic than Mstn(+/+) muscles, suggesting that they might not perform endurance exercise as well as Mstn(+/+) mice. Indeed, it has previously been shown that treadmill exercise training reduces triceps weight in Mstn(-/-) mice. To analyze the response of Mstn(-/-) muscle to endurance exercise in detail, we carried out endurance training over 4 weeks to e ...[more]
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