Ontology highlight
ABSTRACT:
SUBMITTER: Puddick J
PROVIDER: S-EPMC3476820 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Puddick Jonathan J Martinus Ryan D RD
Cell biology international reports 20111130 2
Myostatin, a secreted protein, is a negative regulator of skeletal muscle growth. Down-regulating its expression increases skeletal muscle mass that is accompanied by a marked change in the fibre composition from one reliant on mitochondrial oxidative metabolism to glycolysis. A comparative proteomic investigation of this altered metabolism was carried out on mitochondria from the gastrocnemius muscle of myostatin-null mice compared with wild-type. Most of the proteins identified showed no signi ...[more]