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ABSTRACT:
SUBMITTER: Frimpong K
PROVIDER: S-EPMC2976581 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20090801 16
Indium-promoted coupling reactions between propargyl aldehydes (1) and alpha-chloropropargylphenyl sulfide are reported. Although water has been shown to accelerate indium metal promoted reactions, the reverse pattern was observed in this series. Use of N-methylformamide (NMF), which has not previously been a solvent known for use in indium-promoted reactions, afforded an acceleration of these Barbier-style reactions compared to water. Indium-promoted reactions in this study also showed excellen ...[more]