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Ligand-Promoted C(sp(3) )-H Olefination en Route to Multi-functionalized Pyrazoles.

ABSTRACT: A Pd-catalyzed/N-heterocycle-directed C(sp(3) )-H olefination has been developed. The monoprotected amino acid ligand (MPAA) is found to significantly promote Pd-catalyzed C(sp(3) )-H olefination for the first time. Cu(OAc)2 instead of Ag(+) salts are used as the terminal oxidant. This reaction provides a useful method for the synthesis of alkylated pyrazoles.

SUBMITTER: Yang W

PROVIDER: S-EPMC4944759 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Ligand-Promoted C(sp(3) )-H Olefination en Route to Multi-functionalized Pyrazoles.

Yang Weibo W Ye Shengqing S Schmidt Yvonne Y Stamos Dean D Yu Jin-Quan JQ

Chemistry (Weinheim an der Bergstrasse, Germany) 20160415 21

A Pd-catalyzed/N-heterocycle-directed C(sp(3) )-H olefination has been developed. The monoprotected amino acid ligand (MPAA) is found to significantly promote Pd-catalyzed C(sp(3) )-H olefination for the first time. Cu(OAc)2 instead of Ag(+) salts are used as the terminal oxidant. This reaction provides a useful method for the synthesis of alkylated pyrazoles. ...[more]

PMID: 26991450

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