Ontology highlight
ABSTRACT:
SUBMITTER: Eapen A
PROVIDER: S-EPMC2978562 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Eapen Asha A Sundivakkam Premanand P Song Yiqiang Y Ravindran Sriram S Ramachandran Amsaveni A Tiruppathi Chinnaswammy C George Anne A
The Journal of biological chemistry 20100914 47
Calcium signaling and calcium transport play a key role during osteoblast differentiation and bone formation. Here, we demonstrate that DMP1 mediated calcium signaling, and its downstream effectors play an essential role in the differentiation of preosteoblasts to fully functional osteoblasts. DMP1, a key regulatory bone matrix protein, can be endocytosed by preosteoblasts, triggering a rise in cytosolic levels of calcium that initiates a series of downstream events leading to cellular stress. T ...[more]