Ontology highlight
ABSTRACT:
SUBMITTER: Sasa K
PROVIDER: S-EPMC6043614 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Sasa Kiyohito K Yoshimura Kentaro K Yamada Atsushi A Suzuki Dai D Miyamoto Yoichi Y Imai Hiroko H Nagayama Kazuhiro K Maki Koutaro K Yamamoto Matsuo M Kamijo Ryutaro R
Scientific reports 20180712 1
Monocarboxylate transporter-1 (MCT-1) is a transmembrane transporter for monocarboxylates including lactate and pyruvate. Silencing Mct1 by its small interfering RNA (siRNA) suppressed the expression of marker genes for osteoblast differentiation, namely, Tnap, Runx2, and Sp7, induced by BMP-2 in mouse myoblastic C2C12 cells. Mct1 siRNA also suppressed alkaline phosphatase activity, as well as expressions of Tnap and Bglap mRNAs in mouse primary osteoblasts. On the other hand, Mct1 siRNA did not ...[more]