Ontology highlight
ABSTRACT:
SUBMITTER: Katritch V
PROVIDER: S-EPMC2980563 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Neuropharmacology 20100715 1
One of the major hurdles in the development of safe and effective drugs targeting G-protein coupled receptors (GPCRs) is finding ligands that are highly selective for a specific receptor subtype. Structural understanding of subtype-specific binding pocket variations and ligand-receptor interactions may greatly facilitate design of selective ligands. To gain insights into the structural basis of ligand subtype selectivity within the family of adenosine receptors (AR: A(1), A(2A), A(2B), and A(3)) ...[more]