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ABSTRACT:
SUBMITTER: Bolcato G
PROVIDER: S-EPMC7278174 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Bolcato Giovanni G Bissaro Maicol M Deganutti Giuseppe G Sturlese Mattia M Moro Stefano S
Biomolecules 20200507 5
Adenosine receptors (ARs), like many otherGprotein-coupledreceptors (GPCRs), are targets of primary interest indrug design. However, one of the main limits for the development of drugs for this class of GPCRs is the complex selectivity profile usually displayed by ligands. Numerous efforts have been madefor clarifying the selectivity of ARs, leading to the development of many ligand-based models. The structure of the AR subtype A<sub>1</sub> (A<sub>1</sub>AR) has been recently solved,providing i ...[more]