Ontology highlight
ABSTRACT:
SUBMITTER: Larsen CP
PROVIDER: S-EPMC2980834 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Larsen C P CP Page A A Linzie K H KH Russell M M Deane T T Stempora L L Strobert E E Penedo M C T MC Ward T T Wiseman R R O'Connor D D Miller W W Sen S S Singh K K Kean L S LS
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20100917 11
In murine models, mixed hematopoietic chimerism induction leads to robust immune tolerance. However, translation to primates and to patients has been difficult. In this study, we used a novel MHC-defined rhesus macaque model to examine the impact of MHC matching on the stability of costimulation blockade-/sirolimus-mediated chimerism, and to probe possible mechanisms of bone marrow rejection after nonmyeloablative transplant. Using busulfan-based pretransplant preparation and maintenance immunos ...[more]