Ontology highlight
ABSTRACT:
SUBMITTER: Gordon NC
PROVIDER: S-EPMC2981237 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Gordon N C NC Png K K Wareham D W DW
Antimicrobial agents and chemotherapy 20100927 12
Multidrug-resistant Acinetobacter baumannii (MDRAB) presents an increasing challenge to health care. Although colistin has been used as a treatment of last resort, there is concern regarding its potential for toxicity and the emergence of resistance. The mechanism of action of colistin, however, raises the possibility of synergy with compounds that are normally inactive against Gram-negative organisms by virtue of the impermeability of the bacterial outer membrane. This study evaluated the effec ...[more]