Ontology highlight
ABSTRACT:
SUBMITTER: Cheung KL
PROVIDER: S-EPMC2982833 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cheung Kevin L Y KL Huen Jennifer J Kakihara Yoshito Y Houry Walid A WA Ortega Joaquin J
Journal of molecular biology 20101008 3
Rvb1 and Rvb2 are essential AAA(+) (ATPases associated with diverse cellular activities) helicases, which are important components of critical complexes such as chromatin remodeling and telomerase complexes. The oligomeric state of the Rvb proteins has been controversial. Independent studies from several groups have described the yeast and human Rvb1/Rvb2 complex both as a single and as a double hexameric ring complex. We found that histidine-tagged constructs of yeast Rvb proteins employed in s ...[more]