Ontology highlight
ABSTRACT:
SUBMITTER: Zhou CY
PROVIDER: S-EPMC5564220 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zhou Coral Y CY Stoddard Caitlin I CI Johnston Jonathan B JB Trnka Michael J MJ Echeverria Ignacia I Palovcak Eugene E Sali Andrej A Burlingame Alma L AL Cheng Yifan Y Narlikar Geeta J GJ
Cell reports 20170601 10
The hexameric AAA+ ATPases Rvb1 and Rvb2 (Rvbs) are essential for diverse processes ranging from metabolic signaling to chromatin remodeling, but their functions are unknown. While originally thought to act as helicases, recent proposals suggest that Rvbs act as protein assembly chaperones. However, experimental evidence for chaperone-like behavior is lacking. Here, we identify a potent protein activator of the Rvbs, a domain in the Ino80 ATPase subunit of the INO80 chromatin-remodeling complex, ...[more]