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Tribenzoatobismuth(III): a new -polymorph.

ABSTRACT: A new polymorph (?) was obtained for an active pharmaceutical ingredient, bis-muth tribenzoate, [Bi(C(6)H(5)CO(2))(3)]. The new ?-polymorph is 1.05 times denser than the previously known polymorph [Rae et al. (1998 ?). Acta Cryst. B54, 438-442]. In the ?-polymorph, the Bi atom is linked with three benzoate anions, each of them acting as a bidentate ligand, and these assemblies with C(3) point symmetry can be considered as 'mol-ecules'. The structure of the ?-polymorph has no polymeric chains, in contrast to the previously known polymorph. The 'mol-ecules' in the ?-polymorph are stacked along [001], so that the phenyl rings of the neighbouring mol-ecules are parallel to each other. Based on the pronounced difference in the crystal structures, one can suppose that two polymorphs should differ in the dissolution kinetics and bioavailability.

SUBMITTER: Tumanov NA

PROVIDER: S-EPMC2983313 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Tribenzoatobismuth(III): a new -polymorph.

Tumanov Nikolay A NA Timakova Evgenia V EV Boldyreva Elena V EV

Acta crystallographica. Section E, Structure reports online 20100911 Pt 10

A new polymorph (β) was obtained for an active pharmaceutical ingredient, bis-muth tribenzoate, [Bi(C(6)H(5)CO(2))(3)]. The new β-polymorph is 1.05 times denser than the previously known polymorph [Rae et al. (1998 ▶). Acta Cryst. B54, 438-442]. In the β-polymorph, the Bi atom is linked with three benzoate anions, each of them acting as a bidentate ligand, and these assemblies with C(3) point symmetry can be considered as 'mol-ecules'. The structure of the β-polymorph has no polymeric chains, in ...[more]

PMID: 21587398

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