Browse
Submit Data
Databases
API
Help

Dataset Information

5 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

(S)-Perillaldehyde azine.

ABSTRACT: The C=N-N=C linkage [torsion angle -172.5?(2)°] in the title azine, C(20)H(28)N(2), adopts a trans conformation. The six-membered rings adopt sofa conformations.

SUBMITTER: Han LL

PROVIDER: S-EPMC2983686 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

(S)-Perillaldehyde azine.

Han Li-Lu LL Shi Jiang-Hua JH Yan De-Peng DP Ng Seik Weng SW

Acta crystallographica. Section E, Structure reports online 20100206 Pt 3

The C=N-N=C linkage [torsion angle -172.5 (2)°] in the title azine, C(20)H(28)N(2), adopts a trans conformation. The six-membered rings adopt sofa conformations. ...[more]

PMID: 21580329

Similar Datasets

2,4-Dimethoxy-benzaldehyde azine.

Project description:The title mol-ecule, C(18)H(20)N(2)O(4), is located on a crystallographic centre of symmetry. The meth-oxy groups are coplanar with the benzene ring [interplanar angles of 14.4?(2) and 3.1?(3)°], indicating a conjugation effect.

| S-EPMC2970277 | biostudies-literature

2,3-Dimeth-oxy-benzaldehyde azine.

Project description:There are one-and-a-half independent mol-ecules in the asymmetric unit of the title compound, C(18)H(20)N(2)O(4). One mol-ecule is centrosymmetric with the mid-point of the N-N bond located on a center of inversion. In the other, which lies on a general position, the benzene rings are aligned at 21.6?(1)°. Weak inter-molecular C-H?O hydrogen bonding is present in the crystal strcture.

| S-EPMC3051495 | biostudies-literature

Thio-phene-2-carbaldehyde azine.

Project description:The asymmetric unit of the title compound, C10H8N2S2, is composed of two independent half-mol-ecules, each residing on a center of symmetry. In the crystal, weak C-H?? inter-actions join the two symmetry-independent molecules together into interlinked chains parallel to [011]. The crystal structure was refined as a two-component pseudo-merohedral twin using the twin law 001 0-10 100. The refined domain fractions are 0.516?(3) and 0.484?(3).

| S-EPMC3685067 | biostudies-literature

1H-Indole-3-carbaldehyde azine.

Project description:The molecule of the title compound, C(18)H(14)N(4), lies on a center of inversion such that there is one half-mol-ecule in the asymmetric unit. The N-N single bond adopts a trans configuration and the indole fused-ring system is nearly coplanar with the -CH=N-N=CH- fragment [dihedral angle = 9.8?(2)°]. Adjacent mol-ecules are linked by indole-azine N-H?N hydrogen bonds into a layer motif.

| S-EPMC2960762 | biostudies-literature

Azine Activation via Silylium Catalysis.

Project description:Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup.

| S-EPMC8154516 | biostudies-literature

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response.

Project description:Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation of cGAS by self-DNA promotes severe autoinflammatory diseases such as Aicardi-Goutières syndrome (AGS); thus, inhibition of cGAS may provide therapeutic benefit in anti-autoimmunity. Here we report that perillaldehyde (PAH), a natural monoterpenoid compound derived from Perilla frutescens, suppresses cytosolic-DNA-induced innate immune responses by inhibiting cGAS activity. Mice treated with PAH are more susceptible to herpes simplex virus type 1 (HSV-1) infection. Moreover, administration with PAH markedly ameliorates self-DNA-induced autoinflammatory responses in a mouse model of AGS. Collectively, our study reveals that PAH can effectively inhibit cGAS-STING signaling and could be developed toward the treatment of cGAS-mediated autoimmune diseases.

| S-EPMC8100446 | biostudies-literature

4-(Diethyl-amino)-salicyl-aldehyde azine.

Project description:The title compound, C(22)H(30)N(4)O(2), has a crystallographic inversion center located at the mid-point of the N-N single bond. Apart from the four ethyl C atoms, the non-H atoms are nearly coplanar with a mean deviation of 0.0596?(2)?Å. An intra-molecular O-H?N hydrogen bond occurs. In the crystal, weak inter-molecular C-H?O hydrogen bonds link the mol-ecules into layers parallel to (100).

| S-EPMC3089320 | biostudies-literature

Biphenyl-4-carbaldehyde azine.

Project description:The complete mol-ecule of the title compound, C(26)H(20)N(2), is generated by crystallographic inversion symmetry. The terminal phenyl ring is twisted by 19.2?(1)° with respect to the adjacent phenyl-ene ring.

| S-EPMC2959875 | biostudies-other

2-Benzyl-oxybenzaldehyde azine.

Project description:The complete mol-ecule of the title compound, C(28)H(24)N(2)O(2), is generated by a centre of inversion (at the mid-point of the N-N bond). The substituents at the ends of the C=N bonds adopt an E,E configuration. The central -CH=N-N=CH- fragment is planar, but as a whole the mol-ecule is not: the benz-yloxy group is rotated about the O-C bond by 69.3?(2)° with respect to the plane of the benzyl-idene hydrazine unit.

| S-EPMC2972184 | biostudies-other

1,3-Dithian-2-one azine.

Project description:In an asymmetric unit of the title compound, C(8)H(12)N(2)S(4), there are two crystallographically independent half mol-ecules lying on inversion centers. One of the mol-ecules is disordered over two positions with relative occupancies of 82.0?(2) and 18.0?(2) for the major and minor components. In the crystal structure, mol-ecules are linked into a three-dimensional framework via inter-molecular C-H?N hydrogen-bonding inter-actions.

| S-EPMC2983825 | biostudies-other

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data