Fc?RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.

ABSTRACT: Cellular Fc? receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fc? receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in Fc?RIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating Fc?Rs. To study the role of individual activating Fc?Rs for IgG subclass activity, we generated an Fc?RIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.

SUBMITTER: Nimmerjahn F 

PROVIDER: S-EPMC2984189 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature