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Phospholipid bilayers are viscoelastic.

ABSTRACT: Lipid bilayers provide the structural framework for cellular membranes, and their character as two-dimensional fluids enables the mobility of membrane macromolecules. Though the existence of membrane fluidity is well established, the nature of this fluidity remains poorly characterized. Three-dimensional fluids as diverse as chocolates and cytoskeletal networks show a rich variety of Newtonian and non-Newtonian dynamics that have been illuminated by contemporary rheological techniques. Applying particle-tracking microrheology to freestanding phospholipid bilayers, we find that the membranes are not simply viscous but rather exhibit viscoelasticity, with an elastic modulus that dominates the response above a characteristic frequency that diverges at the fluid-gel (L(?) - L(?)) phase-transition temperature. These findings fundamentally alter our picture of the nature of lipid bilayers and the mechanics of membrane environments.

SUBMITTER: Harland CW

PROVIDER: S-EPMC2984223 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Phospholipid bilayers are viscoelastic.

Harland Christopher W CW Bradley Miranda J MJ Parthasarathy Raghuveer R

Proceedings of the National Academy of Sciences of the United States of America 20101025 45

Lipid bilayers provide the structural framework for cellular membranes, and their character as two-dimensional fluids enables the mobility of membrane macromolecules. Though the existence of membrane fluidity is well established, the nature of this fluidity remains poorly characterized. Three-dimensional fluids as diverse as chocolates and cytoskeletal networks show a rich variety of Newtonian and non-Newtonian dynamics that have been illuminated by contemporary rheological techniques. Applying ...[more]

PMID: 20974934

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