Phospholipid complexation of general anesthetics in fluid bilayers.

ABSTRACT: A nearest-neighbor recognition analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a fundamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC forms 1:1 complexes with CHCl(3) in both membranes in the fluid bilayer state.

SUBMITTER: Turkyilmaz S 

PROVIDER: S-EPMC2856843 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature