Ontology highlight
ABSTRACT:
SUBMITTER: Qu A
PROVIDER: S-EPMC2984533 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Qu Aijuan A Shah Yatrik M YM Matsubara Tsutomu T Yang Qian Q Gonzalez Frank J FJ
Toxicological sciences : an official journal of the Society of Toxicology 20100902 2
Peroxisome proliferator-activated receptor-α (PPARα) mediates the diverse biological effects of peroxisome proliferator (PP) chemicals, including fatty acid catabolism, hepatomegaly, hepatocyte proliferation, and hepatocarcinogenesis in rodents. However, transgenic mice expressing a constitutively active PPARα in hepatocytes (VP16PPARα) do not develop hepatocellular carcinomas in spite of hepatocyte proliferation and hepatomegaly; this suggests that activation of genes in nonparenchymal cells ma ...[more]