Ontology highlight
ABSTRACT:
SUBMITTER: FitzGerald LM
PROVIDER: S-EPMC2986161 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
FitzGerald Liesel M LM Patterson Briony B Thomson Russell R Polanowski Andrea A Quinn Stephen S Brohede Jesper J Thornton Timothy T Challis David D Mackey David A DA Dwyer Terence T Foote Simon S Hannan Garry N GN Stankovich James J McKay James D JD Dickinson Joanne L JL
European journal of human genetics : EJHG 20081001 3
Genetic heterogeneity is a difficulty frequently encountered in the search for genes conferring susceptibility to prostate cancer. To circumvent this issue, we selected a large prostate cancer pedigree for genome-wide linkage analysis from a population that is genetically homogeneous. Selected cases and first-degree relatives were genotyped with Affymetrix 10K SNP arrays, identifying a 14 Mb haplotype on chromosome 5 (5p13-q12) inherited identical-by-descent (IBD) by multiple cases. Microsatelli ...[more]