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Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

ABSTRACT: We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

SUBMITTER: Yeager M 

PROVIDER: S-EPMC3430510 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

Yeager Meredith M   Chatterjee Nilanjan N   Ciampa Julia J   Jacobs Kevin B KB   Gonzalez-Bosquet Jesus J   Hayes Richard B RB   Kraft Peter P   Wacholder Sholom S   Orr Nick N   Berndt Sonja S   Yu Kai K   Hutchinson Amy A   Wang Zhaoming Z   Amundadottir Laufey L   Feigelson Heather Spencer HS   Thun Michael J MJ   Diver W Ryan WR   Albanes Demetrius D   Virtamo Jarmo J   Weinstein Stephanie S   Schumacher Fredrick R FR   Cancel-Tassin Geraldine G   Cussenot Olivier O   Valeri Antoine A   Andriole Gerald L GL   Crawford E David ED   Haiman Christopher A CA   Henderson Brian B   Kolonel Laurence L   Le Marchand Loic L   Siddiq Afshan A   Riboli Elio E   Key Timothy J TJ   Kaaks Rudolf R   Isaacs William W   Isaacs Sarah S   Wiley Kathleen E KE   Gronberg Henrik H   Wiklund Fredrik F   Stattin Pär P   Xu Jianfeng J   Zheng S Lilly SL   Sun Jielin J   Vatten Lars J LJ   Hveem Kristian K   Kumle Merethe M   Tucker Margaret M   Gerhard Daniela S DS   Hoover Robert N RN   Fraumeni Joseph F JF   Hunter David J DJ   Thomas Gilles G   Chanock Stephen J SJ  

Nature genetics 20090920 10

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24. ...[more]

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