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GAB2 is not associated with late-onset Alzheimer's disease in Japanese.

ABSTRACT: The varepsilon4 allele of the apolipoprotein E gene (APOE) is unequivocally recognized as a genetic risk factor for late-onset Alzheimer's disease (LOAD). Recently, single-nucleotide polymorphisms (SNPs) of the GRB2-associated binding protein 2 gene (GAB2) were shown to be associated with LOAD in Caucasians carrying the APOE-varepsilon4 allele through a genome-wide association study. Here, we attempted to replicate the finding by genotyping these SNPs in a large clinical cohort of Japanese. We observed no association of any of the SNPs with LOAD. GAB2 may not be a disease susceptibility gene for LOAD in Japanese.

SUBMITTER: Miyashita A

PROVIDER: S-EPMC2986257 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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GAB2 is not associated with late-onset Alzheimer's disease in Japanese.

Miyashita Akinori A Arai Hiroyuki H Asada Takashi T Imagawa Masaki M Shoji Mikio M Higuchi Susumu S Urakami Katsuya K Toyabe Shinichi S Akazawa Kohei K Kanazawa Ichiro I Ihara Yasuo Y Kuwano Ryozo R

European journal of human genetics : EJHG 20081015 5

The varepsilon4 allele of the apolipoprotein E gene (APOE) is unequivocally recognized as a genetic risk factor for late-onset Alzheimer's disease (LOAD). Recently, single-nucleotide polymorphisms (SNPs) of the GRB2-associated binding protein 2 gene (GAB2) were shown to be associated with LOAD in Caucasians carrying the APOE-varepsilon4 allele through a genome-wide association study. Here, we attempted to replicate the finding by genotyping these SNPs in a large clinical cohort of Japanese. We o ...[more]

PMID: 18854865

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