Ontology highlight
ABSTRACT:
SUBMITTER: Emily M
PROVIDER: S-EPMC2986645 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
European journal of human genetics : EJHG 20090311 10
Genome-wide association studies have identified a large number of single-nucleotide polymorphisms (SNPs) that individually predispose to diseases. However, many genetic risk factors remain unaccounted for. Proteins coded by genes interact in the cell, and it is most likely that certain variants mainly affect the phenotype in combination with other variants, termed epistasis. An exhaustive search for epistatic effects is computationally demanding, as several billions of SNP pairs exist for typica ...[more]