Biological interpretation of genome-wide association studies using predicted gene functions.
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ABSTRACT:
SUBMITTER: Pers TH
PROVIDER: S-EPMC4420238 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Biological interpretation of genome-wide association studies using predicted gene functions.
Pers Tune H TH Karjalainen Juha M JM Chan Yingleong Y Westra Harm-Jan HJ Wood Andrew R AR Yang Jian J Lui Julian C JC Vedantam Sailaja S Gustafsson Stefan S Esko Tonu T Frayling Tim T Speliotes Elizabeth K EK Boehnke Michael M Raychaudhuri Soumya S Fehrmann Rudolf S N RS Hirschhorn Joel N JN Franke Lude L
Nature communications 20150119
The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant ...[more]
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