Ontology highlight
ABSTRACT:
SUBMITTER: May L
PROVIDER: S-EPMC2987239 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
May Linda L van Bodegom David D Frölich Marijke M van Lieshout Lisette L Slagboom P Eline PE Westendorp Rudi G J RG Kuningas Maris M
European journal of human genetics : EJHG 20091021 4
Toll-like receptors (TLRs) are involved in the induction of an adequate immune response on infection. We hypothesized that genetic variation in TLR4 and TLR2 genes could influence this response and lead to variability in cytokine production and survival. We tested this hypothesis in 4292 participants who were followed up for all-cause mortality for 6 years and live under adverse environmental conditions in the Upper-East region of Ghana, where malaria is endemic. In 605 participants, tumor necro ...[more]