Ontology highlight
ABSTRACT:
SUBMITTER: Lau MY
PROVIDER: S-EPMC5337969 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lau Melisa Y Z MY Dharmage Shyamali C SC Burgess John A JA Win Aung K AK Lowe Adrian J AJ Lodge Caroline C Perret Jennifer J Hui Jennie J Thomas Paul S PS Morrison Stephen S Giles Graham G GG Hopper John J Abramson Michael J MJ Walters E Haydn EH Matheson Melanie C MC
Scientific reports 20170306
Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies of microbial exposure (childhood farm exposure and childhood rural environment). Ten SNPs in four genes (TLR2, TLR4, TLR6, CD14) were genotyped for 1,116 participants from the Tasman ...[more]