Ontology highlight
ABSTRACT:
SUBMITTER: Berulava T
PROVIDER: S-EPMC2987405 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
European journal of human genetics : EJHG 20100526 9
As shown by genome-wide association studies single-nucleotide polymorphisms (SNPs) within intron 1 of the FTO gene are associated with the body mass index and type II diabetes, although the functional significance of these SNPs has remained unclear. Using primer extension assays, we have determined the ratio of allelic FTO transcript levels in unspliced heterogeneous nuclear RNA preparations from blood of individuals heterozygous for SNP rs9939609. Allelic expression ratios of the neighboring RP ...[more]