Ontology highlight
ABSTRACT:
SUBMITTER: Turbiak AJ
PROVIDER: S-EPMC2987637 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Turbiak Anjanette J AJ Kampf Jeff W JW Hollis Showalter H D HD
Tetrahedron letters 20100301 9
An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl) uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by selenium dioxide oxidation of the corresponding phenyl and alkyl methyl ketones. The first entry into 4-monosubstituted isomers is also reported. ...[more]