Ontology highlight
ABSTRACT:
SUBMITTER: Kobelev AI
PROVIDER: S-EPMC6902856 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20191127
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [<i>e</i>]-fused 1<i>H</i>-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without ...[more]