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Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea.


ABSTRACT: A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods.

SUBMITTER: Kobelev AI 

PROVIDER: S-EPMC6902856 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [<i>e</i>]-fused 1<i>H</i>-pyrrole-2,3-diones with thiourea.

Kobelev Aleksandr I AI   Tretyakov Nikita A NA   Stepanova Ekaterina E EE   Dmitriev Maksim V MV   Rubin Michael M   Maslivets Andrey N AN  

Beilstein journal of organic chemistry 20191127


A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [<i>e</i>]-fused 1<i>H</i>-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without  ...[more]

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