Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification.

ABSTRACT:

Objective

The vitamin D endocrine system is essential for calcium homeostasis, and low levels of vitamin D metabolites have been associated with cardiovascular disease risk. We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC).

Methods and results

We genotyped single-nucleotide polymorphisms (SNPs) in GC, CYP27B1, CYP24A1, and VDR and tested their association with CAC quantity, as measured by electron beam computed tomography. Initial association studies were carried out in a discovery sample comprising 697 Amish subjects, and SNPs nominally associated with CAC quantity (4 SNPs in CYP24A1, P=0.008 to 0.00003) were then tested for association with CAC quanti

SUBMITTER: Shen H 

PROVIDER: S-EPMC2988112 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature