Ontology highlight
ABSTRACT:
SUBMITTER: Brew K
PROVIDER: S-EPMC2988317 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Brew Keith K Tumbale Percy P Acharya K Ravi KR
The Journal of biological chemistry 20100924 48
Glycosyltransferases (GTs) control the synthesis and structures of glycans. Inactivation and intense allelic variation in members of the GT6 family generate species-specific and individual variations in carbohydrate structures, including histo-blood group oligosaccharides, resulting in anti-glycan antibodies that target glycan-decorated pathogens. GT6 genes are ubiquitous in vertebrates but are otherwise rare, existing in a few bacteria, one protozoan, and cyanophages, suggesting lateral gene tr ...[more]