Ontology highlight
ABSTRACT:
SUBMITTER: Scherrer T
PROVIDER: S-EPMC2988813 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Scherrer Tanja T Mittal Nitish N Janga Sarath Chandra SC Gerber André P AP
PloS one 20101111 11
Hundreds of RNA-binding proteins (RBPs) control diverse aspects of post-transcriptional gene regulation. To identify novel and unconventional RBPs, we probed high-density protein microarrays with fluorescently labeled RNA and selected 200 proteins that reproducibly interacted with different types of RNA from budding yeast Saccharomyces cerevisiae. Surprisingly, more than half of these proteins represent previously known enzymes, many of them acting in metabolism, providing opportunities to direc ...[more]